We identified the pro-tumor and anti-ferroptosis functions of MTTP in gastric cancer (GC) cells by <i>in vitro</i> and <i>in vivo</i> experiments, and analyzed the effect of TME on ferroptosis by single-cell sequencing.<h4>Results</h4>MTTP expression was elevated in at least 1/3 tumors. Here, MTTP is linked to neoplasm.