At the heart of their design lies the TCPP component, which, when stimulated by near‐infrared light, triggers a photodynamic reaction, releasing reactive oxygen species (ROS) within the tumor milieu.[37, 38] This cascade of ROS serves a twofold purpose: direct cytotoxic effects causing cellular membrane damage and consequent cell death, and strategic interference with glucose metabolism.[39, 40, 41, 42] Such intervention enhances the precision targeting of metformin and FOXK2 siRNA on these metabolic pathways, accentuating their collective antitumor prowess. This evidence concerns the gene FOXK2 and neoplasm.