Cluster analysis revealed key thematic areas in the field, including "incretin-based therapy," "dipeptidyl peptidase-4 inhibition," and "cardiovascular safety." Emerging clusters, such as "atrial fibrillation," have gained attention in recent years, highlighting evolving areas of investigation.<h4>Conclusion</h4>This study underscores the importance of CVOs in the research on DPP-4 inhibitors. The gene discussed is DPP4; the disease is atrial fibrillation.