Therefore, the patient was treated with manual TWBE and intravenous vitamin C. Several published reports have illustrated the successful use of TWBE in the treatment of methemoglobinemia in settings where methylene blue was unavailable.<h4>Conclusion</h4>A thorough clinical evaluation is key in diagnosing methemoglobinemia in circumstances where specific tests to detect methemoglobin are not available. This evidence concerns the gene HBG2 and methemoglobinemia.