Some well‐characterised BMP antagonists include Noggin, which has been implicated in promoting skin and breast cancer tumorigenesis; the Gremlins (encoded by GREM1 and GREM2), with repression of Gremlin1 shown to inhibit tumour cell proliferation; and the Chordin family of proteins, including Chordin (encoded by CHRD), Chordin‐like 1 (CHRDL1), and Chordin‐like 2 (CHRDL2) [39, 40, 41, 42] (Table 1). This evidence concerns the gene GREM1 and neoplasm.