To validate the functional role of Lgr6 in pathological cardiac hypertrophy, we generated AAVs carrying the cTnT promoter to selectively enhance Lgr6 expression in mouse cardiomyocytes (AAV9‐cTnT‐Lgr6 and AAV9‐cTnT‐null) (Figure S6, Supporting Information). Here, TNNT2 is linked to cardiac hypertrophy.