As one of the classic downstream signals of PKG, cAMP response element binding protein 1 (CREB1) has been reported to regulate PO‐induced cardiac hypertrophy.[23] In our study, Lgr6 overexpression effectively promoted the phosphorylation level of CREB1 in NRCMs under PE conditions (Figure 7I). Here, LGR6 is linked to cardiac hypertrophy.