Our previous studies have shown that Lgr6 overexpression can effectively alleviate diabetic cardiomyopathy and myocardial ischemia‐reperfusion injury.[16, 19] This study further suggests the important role of Lgr6 in cardiac hypertrophy, indicating that Lgr6 may be an important target for regulating cardiovascular diseases. Here, LGR6 is linked to cardiovascular disorder.