GPCRs have been reported to play an important role in cardiac hypertrophy.[11] To investigate genes with functional significance in the G protein‐coupled receptor activity pathway, we further analyzed the differentially expressed genes (DEGs) in the G protein‐coupled receptor activity pathway and identified 11 downregulated genes, among which the downregulation of Lgr6 was most prominent in PO hearts (Figure1A). This evidence concerns the gene LGR6 and cardiac hypertrophy.