Our previous studies have shown that Lgr6 overexpression can effectively alleviate diabetic cardiomyopathy and myocardial ischemia‐reperfusion injury.[16, 19] This study further suggests the important role of Lgr6 in cardiac hypertrophy, indicating that Lgr6 may be an important target for regulating cardiovascular diseases. The gene discussed is LGR6; the disease is ischemia.