Furthermore, miR-103 were previously predicted by bioinformatics to affect multiple mRNA targets in pathways that involve cellular acetyl-CoA and lipid levels [28], which were significantly upregulated in ob/ob mice, suggesting the potential role of in the pathogenesis of nonalcoholic fatty liver disease and confirm central importance to glucose homeostasis and insulin sensitivity, was only detected at a moderate level in yak in our study. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.