Canopy fibroblast growth factor (FGF) signaling regulator 2 (CNPY2) is localized in the ER and serves as a significant regulatory factor in ERS.[17] Previous studies have indicated that CNPY2 plays a crucial role in activating the protein kinase R (PKR)‐like ER kinase (PERK) pathway in response to unfolded proteins in the ERS, thereby influencing cellular processes such as cell growth, migration, and apoptosis.[17] However, the specific role of CNPY2 in the pathogenesis of DN remains unclear. The gene discussed is EIF2AK2; the disease is liver dysplastic nodule.