After adjustments for age, sex, body mass index, smoking, diabetes status, systolic and diastolic blood pressure, total cholesterol, high‐ and low‐cholesterol, triglycerides, Lp(a) and DNAJA4 levels (Model 4), circulating PDAP1 levels, both in each‐unit increase and the categorical analysis to a tertile change (high‐, middle‐ and low‐group), were significantly associated with a higher risk of all‐cause mortality (p = 0.01 and 0.003, respectively, Figure 3D,E and Table S10). This evidence concerns the gene LPA and diabetes mellitus.