The binding of E2F3 to the promoter of FGF2, confirmed by ChIP-qPCR, increases FGF2 expression, thereby promoting tumor proliferation and metastasis by activating FGFR1, PI3K/Akt, and MEK/ERK signaling pathways in HCC cells [47]. This evidence concerns the gene FGF2 and hepatocellular carcinoma.