Among 120 HCC tissue samples from patients, we found that the Wnt pathway activation, evaluated as nuclear translocation of beta-catenin, was associated with the higher percentage of PD-L1 positive cells among tumor cells (p = 0.05, Figure S2A) and all cells (p = 0.025, Figure S2B) in the tissue. This evidence concerns the gene CD274 and hepatocellular carcinoma.