The most common grade ≥ 3 biochemical DR-AEs were CPK and ALT/AST increases and grade ≥ 3 non haematological/biochemical DR-AEs were fatigue, oedema, decrease in left ventricular ejection fraction, pleural effusion, dyspnoea, postural hypotension and pneumonia, observed in 10 patients (50%) (Supplementary Table S3). Here, PIK3C2A is linked to Pleural effusion.