The most common DR-AE’s were rash (95%), followed by fatigue (70%), diarrhoea (65%), nausea (45%), oedema (40%), CPK increases (40%), AST/ALT increases (25%), vomiting (20%), arthralgia/myalgia (20%), blurred vision (20%) and peripheral neuropathy (20%) (Table 3). The gene discussed is GPT; the disease is peripheral neuropathy.