These latter findings confirm and extend observations by Zeng et al. [56 ]and Fan and colleagues [57] that ZFAS1 is elevated in NSCLC and enhances the growth and invasion of lung cancer cells by modulating the expression of high mobility group AT-hook 2 (HMGA2) and fibroblast growth factor receptor substrate 2 (FRS2), respectively. Here, HMGA2 is linked to non-small cell lung carcinoma.