With 198 genes and 20 key driver genes, GRN195 contributed 0.6% of CAD H2 and contained 7 CAD GWAS candidate genes: FLT1, NOS3, PECAM1, PLCG2, PLEKHG1, TEK and THSD7A (Fig. 7g, upper panel). Here, PLEKHG1 is linked to coronary artery disorder.