The SMC-dominant (Fig. 5f,g) GRN177 contained 43 key drivers and 19 CAD genome wide association studies (GWAS) candidate genes (ANKRD6, ARHGAP26, CNNM2, FNDC3B, GEM, HECA, MAP1B, MAP3K7CL, NBEAL1, NEDD9, NT5C2, PALLD, PDLIM5, PPP1R12B, PREX1, RAB23, RUNX2, SHROOM3, and SLC22A3) and contributed to 2.16% of CAD H2 (Fig. 5g). Here, SLC22A3 is linked to coronary artery disorder.