The MP-dominated GRN33 (Fig. 6f,g, upper panel) contained 33 key drivers, contributed to 1.14% of CAD H2 and harbored 10 CAD GWAS candidate genes (Fig. 6g; CXCL8, LDLR, MAT2A, MCL1, OSM, PKD2L1, RASGEF1B, PKD2L1, SLC22A4 and TRIB1). The gene discussed is PKD2L1; the disease is coronary artery disorder.