The SMC-dominant (Fig. 5f,g) GRN177 contained 43 key drivers and 19 CAD genome wide association studies (GWAS) candidate genes (ANKRD6, ARHGAP26, CNNM2, FNDC3B, GEM, HECA, MAP1B, MAP3K7CL, NBEAL1, NEDD9, NT5C2, PALLD, PDLIM5, PPP1R12B, PREX1, RAB23, RUNX2, SHROOM3, and SLC22A3) and contributed to 2.16% of CAD H2 (Fig. 5g). This evidence concerns the gene RUNX2 and coronary artery disorder.