GRN174 had 27 key drivers, contributed 1.58% of CAD H2 and harbored 12 CAD candidate GWAS genes (Fig. 6g, lower panel; ARHGAP15, CD300LF, CTSS, LINC00861, MAP3K1, NUP210, PLCB2, RUNX2, SCML4, SERPINA1, TBXAS1, ZNF831). Here, RUNX2 is linked to coronary artery disorder.