GRN122 contributed to a remarkable 4.10% of CAD H2 and contained 16 CAD GWAS candidate genes: ARHGAP15, C2, CFAP161, CTSS, EDEM2, MITF, NPC1, PID1, PLCB2, SCARB1, SERPINA1, TARID, TBXAS1, VAMP8, ZC3H12D and ZNF831 (Fig. 7f,g, lower panels). The gene discussed is NPC1; the disease is coronary artery disorder.