During atherosclerosis progression in female Ldlr−/−Apob100/100 mice, the expression levels of the top key driver, LYZ, increased and LYZ was upregulated in female versus male carotid plaques (Fig. 6h, lower panels) suggesting that it may be a suitable target to modulate GRN174 activity specifically in females. The gene discussed is LYZ; the disease is atherosclerosis.