By deleting YTHDF1 selectively in D1 and D2 striatal neurons [295, 296], our own studies have found that YTHDF1 deficiency in D1 neurons selectively impaired the acquisition of motor skill learning whereas YTHDF1 deficiency in D2 neurons virtually eliminated inhibitory motor learning in PD models and haloperidol-induced catalepsy in drug-induced parkinsonism models. The gene discussed is YTHDF1; the disease is Parkinsonism.