CLPP and neuroblastoma: In our previous study [5], ONC201 suppressed the expression of ClpP and caseinolytic mitochondrial matrix peptidase proteolytic subunit X (ClpX), while downregulating the mitochondrial respiratory chain subunits succinate dehydrogenase complex iron sulfur subunit B (SDHB) and NADH/ubiquinone oxidoreductase core subunit S1 (NDUFS1); these effects resulted in energy depletion and increased reactive oxygen species (ROS) levels, along with suppression of NB cell growth, regardless of MYCN amplification status.