GLP1R and Cognitive impairment: This distribution suggests a direct influence of the GLP-1 system on neural function, making GLP-1RAs promising candidates for addressing cognitive disorders.9 10 Their neuroprotective effects had already been postulated three decades ago when it was found that a component of Gila monster’s venom, the peptide exendin-4, could be synthesised in a drug called exenatide for use in diabetes, dementias and other chronic diseases common to older age.11 12