GLP-1RAs are a class of medications currently including exenatide, lixisenatide, dulaglutide, liraglutide, semaglutide and tirzepatide (a dual GLP-1/gastric inhibitory polypeptide (GIP) receptor agonist), initially developed for type 2 diabetes mellitus (T2DM).6 The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.