SLC22A12 and hypouricemia, renal: Notably, given the pathophysiological features of renal hypouricemia, which is an inherited disorder caused by increased urinary urate excretion that results from the complete dysfunction of URAT1 or GLUT9 (8), renal urate reuptake primarily depends on the URAT1–GLUT9 axis, and apparent urate secretion from the renal epithelial cells into the blood is mostly governed by GLUT9.