ERN1 and neoplasm: Furthermore, tumor samples from AMO1 and KMS27 xenografts exhibited marked downregulation of UHRF1 for both cell lines, in concert with upregulation of p53, p21 (only for AMO1), and p27 (for both AMO1 and KMS27) in the context of Dox-induced IRE1 silencing but not enzymatic inhibition (S5F and S5G Fig).