Histological grade was substituted for nuclear grade and defined as follows for Cohort 1 and Cohort 2: Cohort 1, patients with either (1) ≥ 4 lymph nodes or (2) 1–3 lymph nodes and tumor size ≥ 5 cm or nuclear Grade 3; Cohort 2, patients with 1–3 lymph nodes, tumor size < 5 cm, nuclear Grade 1 or 2, and Ki-67 ≥ 20%. This evidence concerns the gene MKI67 and neoplasm.