Evidence has shown that PA metabolism is associated with elevated levels of cytosolic free Ca2+ in hypothalamic neurons and differentiated neuroblastoma cells [67, 108] One protein that senses Ca2+ levels is calmodulin (CaM), whose interaction with the kinase CaMKII, due to the disruption of Ca2+ homeostasis, has been implicated in AD. Here, CAMK2G is linked to Alzheimer disease.