FZD7 and hepatocellular carcinoma: In addition, it was reported that miR-485-5p directly targets the Frizzled-7 (FZD7) receptor to inhibit the Wnt/β-catenin signal pathway with negative regulation of both cytoplasmic and nuclear β-catenin, and the expression of Wnt/β-catenin pathway downstream targets c-Myc and cyclin D1 in HCC cells [42].