The miR-485-5p displayed a better performance with greater area under the ROC curve (AUC) and a higher sensitivity and specificity than AFP in predicting HCC in HCV-related liver cirrhosis (AUC, sensitivity, and specificity of 0.921, 92.0, and 84.0 for miR-485-5p, and 0.704, 64.0, and 60.0 for AFP, respectively) (Fig. 4). Here, AFP is linked to cirrhosis of liver.