Lynch syndrome (LS) is caused by germline pathogenic variants in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. People with Lynch syndrome have an increased risk of colorectal cancer (CRC), endometrial cancer (EC), and other cancers, including sebaceous neoplasms [1]. The gene discussed is MLH1; the disease is sebaceous gland neoplasm.