MLH1 promoter methylation testing of non-Lynch syndrome cases without a germline pathogenic variant in the MLH1 gene was performed on sebaceous neoplasm tissue DNA (n = 10) and blood-derived DNA (n = 17) using Methylight with cases positive for MLH1 promoter methylation undergoing confirmation testing using methylation-sensitive high resolution melting (MS-HRM) as previously described [4, 7]. This evidence concerns the gene MLH1 and Lynch syndrome.