PDGFRA and idiopathic pulmonary arterial hypertension: We observed frequent PCNA+ fibroblasts, identified by PDGFRA staining, in the adventitial layer of PA from IPAH patients (Figure 3G), while decreased percentage of proliferating PASMC in IPAH PA, detected by PCNA and Ki-67 staining, was reported previously (Crnkovic et al., 2022).