However, the expression pattern and mechanism of actions of miR-122 remain primarily unknown in colon cancer.<h4>Methods</h4>In this study, we analyzed The Cancer Genome Atlas Colon Adenocarcinoma (TCGA-COAD) database to assess the clinical significance of astrocyte elevated gene-1 (AEG-1)/metadherin (MTDH) and miR-122 in colon cancer. The gene discussed is MTDH; the disease is colon adenocarcinoma.