We have shown that these ASYMP epitopes in tandem with CXCL-11 and IL1/IL15, PPK vaccine given therapeutically to latently infected HLA Tg rabbits: (i) significantly decrease virus reactivation from TG (virus shedding in tears) and/or recurrent ocular disease and (ii) increase the numbers and functions of local HSV 1 glycoproteins D and B (gD and gB), viral tegument proteins (VP11/12 and VP13/14) and the DNA replication-binding helicase (UL9) epitopes specific CD8+ T cells over the existing immune response induced by the primary infection. This evidence concerns the gene CD8A and infection.