In recent years, Selenium research has attracted tremendous interest because of its important role in antioxidant selenoproteins for protection against oxidative stress initiated by excess ROS and reactive nitrogen species (Tinggi, 2008); (Björklund et al., 2022); (Zakeri et al., 2021). DED is related to oxidative stress and selenium compounds are probably candidates for treatment of dry eye by regulating oxidative stress in the corneal epithelium (Higuchi et al., 2012); (Higuchi et al., 2016); (Pasricha, 2023). The gene discussed is SELENOS; the disease is Keratoconjunctivitis sicca.