We aimed to conduct a systematic review and <i>meta</i>-analysis of studies on the effects of HIF-PH inhibitors on hemoglobin, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), or estimated glomerular filtration rate (eGFR) in HF patients with chronic kidney disease (CKD).<h4>Methods and results</h4>The search of electronic databases identified four studies including 98 patients. Here, NPPB is linked to hydrops fetalis.