This study aims to evaluate the impact of using a vHPSD catheter compared to an STD RF one, on variations in Brain Natriuretic Peptide (BNP), high‐sensitivity Troponin I (hsTnI), and C‐reactive protein (CRP) as biomarkers of heart failure, myocardial injury, and systemic inflammation, respectively. The gene discussed is NPPB; the disease is heart failure.