Protein expression analysis revealed that these genes were downregulated in placental tissues from preeclampsia patients compared to healthy controls.<h4>Discussions</h4><i>TYROBP, PLEK, LCP2, HCK, and ITGAM</i> are closely linked to preeclampsia and hold promise as potential biomarkers for its diagnosis and for advancing the understanding of its pathogenesis. This evidence concerns the gene PLEK and preeclampsia.