Bioinformatics methods including quality control, dimensionality reduction, cell annotation, differential expression analysis, cell communication analysis, and co-expression network analysis were employed for data processing and analysis.<h4>Results</h4>This study utilized single-cell sequencing technology to uncover the dynamics of immune cell communication during the course of KD, revealing a significant increase in the number of CD14<sup>+</sup> monocytes in the early stages of vasculitis, which play a central role in cell-cell communication. Here, CD14 is linked to vasculitis.