ZBP1 and sporotrichosis: This study aimed to detect PANoptosis regulatory protein ZBP1 expression in the skin lesions of patients with sporotrichosis, reveal the exact mechanism of Nd:YAG1064nm laser against sporotrichosis, and provide novel targets and methods for the diagnosis, assessment, and treatment of sporotrichosis.<h4>Methodology/principal findings</h4>The ZBP1 level of 60 patients with sporotrichosis (≤3 months; <i>n</i> = 30 and >3 months; <i>n</i> = 30) and 30 HC were retrospectively reviewed using immunohistochemistry.