Conversely, other indicators, including Aβ42, Aβ42/40, T-tau/Aβ42, P-tau217/Aβ42 and P-tau181, demonstrated some diagnostic efficacy but fell short of meeting the diagnostic criteria.<h4>Discussion</h4>P-tau217 stands out as a highly effective biomarker for distinguishing AD from CUC, exhibiting extensive clinical application potential in the Chinese population. The gene discussed is MAPT; the disease is Alzheimer disease.