Additional significant genetic causes of DCM include variants in lamin A/C (LMNA), which are identified in approximately 5 % of DCM cases, RNA-binding motif-20 (RBM20), filamin C (FLCN), desmin (DES), and desmoplakin (DSP) [21, 34, 35]. Here, DSP is linked to familial dilated cardiomyopathy.