The expression of proteins in IKK/NF-κB and NLRP3 inflammasome signal pathway were analyzed.<h4>Results</h4>We found that CMS induced depressive-like behaviors as well as hypomagnesemia in mice, which were accompanied with hypersecretion of inflammatory cytokines in hippocampus of mice. Here, NFKB1 is linked to Hypomagnesemia.