The primary network also highlighted that AOP382 and AOP319 described overlapping KEs of a same pathway involving RAS up to lung fibrosis and have been therefore merged into one AOP (AOP319) as such: ACE2 downregulation > Ang II accumulation > Ang II-AT1R activation > ROS regeneration > Collagen deposition > lung fibrosis. Here, ACE2 is linked to pulmonary fibrosis.