Overexpression of COPB1 can restore osteogenic function in both cells and mice.<h4>Conclusion</h4>This study elucidated the essential role of COPB1 in maintaining bone homeostasis and highlights it as a potential therapeutic target for treating iron accumulation-related osteoporosis.<h4>The translational potential of this article</h4>Our data elucidate the critical role of COPB1 in maintaining bone homeostasis and demonstrate that COPB1 can directly promote bone formation, making it a potential therapeutic target for the future treatment of osteoporosis. The gene discussed is COPB1; the disease is osteoporosis.