The effect of C8orf76 on lung adenocarcinoma (LUAD) is unknown.<h4>Methods</h4>Multi-omics pan-cancer analysis by utilizing datasets including UALCAN, TIMER 2.0, Human Protein Atlas (HPA), The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), cBioPortal, Gene Expression Profiling Interactive Analysis (GEPIA), OncoDB, and MethSurv datasets, were conducted to analyze C8orf76 across 33 cancer types. The gene discussed is C8orf76; the disease is lung adenocarcinoma.