Analysis of overlapping downregulated DEGs in the leishmaniasis and toxoplasmosis pathways identified key association with Tnf, Mapk11, Tbfb3, Stat1, and MHC Class II-related genes (H2-Oa, H2-DMb1, H2-Aa, H2-Dma, H2-Eb1, and H2-Ab1). This evidence concerns the gene MAPK11 and leishmaniasis.