PIK3CA and neoplasm: A significant downstream target of the PI3K/AKT pathway is mTOR, whose activation leads to the phosphorylation of ribosomal protein S6 kinase (S6K) and eukaryotic translation initiation factor 4E (eIF4E)‐binding protein 1 (4EBP‐1), which facilitates the transcription, proliferation, growth, and protein synthesis of tumor cells [6, 8, 21, 25, 27].