ZDHHC17 and Familial prostate cancer: For example, ZDHHC14 is linked to prostate cancer and testicular germ cell tumors where it showed only a low expression and has been identified to act as a tumor suppressor.[25] In contrast, ZDHHC17 is hypothesized to act as an oncogene as ZDHHC17 mRNA is overexpressed in many cancers, including breast, prostate, stomach, lung, and colon cancer.[26, 27]