EZH2 and Huntington disease: The identified lower levels of H3K27me3 seen in heterozygous expanded polyQ HTT-expressing striatum and, in particular, the lack of changes in EZH2 occupancy might implicate H3K27-targeted histone demethylases, such as KDM6A/UTX, in epigenetic changes observed in HD (Song et al., 2018).