HTT and Huntington disease: Transcriptional (Cha, 2007) and epigenomic (Achour et al., 2015; Bassi et al., 2017; Le Gras et al., 2017; Alcalá-Vida et al., 2021) dysregulation are among the earliest phenotypes in cells and tissues expressing mutant HTT protein (mHTT), an observation that is reproducible and shared between brain tissue from humans with HD and in mouse models (Ament et al., 2017; Hodges et al., 2006; Langfelder et al., 2016).