APC and neoplasm: Mice with monoallelic disruption of Apc specifically in the colon develop a robust increase in colon adenomatous polyps within 3 months, and dextran sodium sulfate (DSS)-induced inflammation accelerates tumor growth to less than 1.5 months (Xue et al., 2016; Yin et al., 2021; Arcos et al., 2024).