In the PONTIAC (NT‐proBNP Selected PreventiOn of cardiac eveNts in a populaTion of dIabetic patients without A history of Cardiac disease) trial, 300 patients with type 2 diabetes and an elevated NT‐proBNP (>125 pg/mL) and free of known cardiac disease were randomised to NT‐proBNP guided medical therapy or standard care.35 This evidence concerns the gene NPPB and type 2 diabetes mellitus.