In a study, apigenin ameliorated diabetic neuropathy in rats by modulating the TLR4/MyD88 signalling pathway, which showed inhibited elevated plasma glucose levels, TNF-α, ILs, TLR4, and MyD88 expressions, thus ameliorating STZ (Streptozotocin) -induced allodynia and hyperalgesia (Fang et al. 2023; Yu et al. 2023). Here, TLR4 is linked to diabetic neuropathy.