BCR and chronic myelogenous leukemia, BCR-ABL1 positive: We found no evidence of TKI-induced mutations, however, recurrent trisomy 8 was observed in BCR::ABL1-negative colonies (Figs. 1f and 2), which could reflect increased proliferation or survival of trisomy 8 HSPCs during CML development, or their subsequent positive selection by TKI.