Indomethacin, among other 44 approved drugs, targets PTGS1, also known as COX1. Treatment with naproxen (one of the approved drugs) suppressed PTGS1 expression in synovial tissue, inhibited the migratory and invasive capabilities of osteoarthritis synoviocytes and increased their apoptosis rate44. Here, PTGS1 is linked to osteoarthritis.