In addition, by encouraging the breakdown of hypoxia-inducible factor 1α(HIF-1α) protein and preventing the stimulation of the PI-3 K/Akt/mTOR/HIF-1α/VEGF axis, dauricine reduces the creation of HIF-1α protein, which in turn prevents angiogenesis in human breast cancer cell lines [45]. The gene discussed is VEGFA; the disease is breast carcinoma.