To summarize, in 1984 we cloned the human BCL1 gene locus involved in mantle cell lymphoma, and then in 1984–1985 we cloned and characterized the human BCL2 gene which is subject to the t14;18 chromosomal translocation found in most cases of follicular lymphoma, one of the most common human lymphomas [12, 13]. Here, BCL2 is linked to lymphoma.