Many studies have indicated that the High Mobility Group A2 (HMGA2) protein is a potential diagnostic and prognostic cancer marker due to its multifaceted role in cancer development and progression (Ding et al. 2014; Wu et al. 2016; Mansoori et al. 2020, 2021a; Gao et al. 2017; Mahajan et al. 2010; Hengjuan Lv et al. 2019; Jin et al. 2011; Yang et al. 2011). This evidence concerns the gene HMGA2 and cancer.